If your dose in the concomitant CYP3A4 inducer can't be lowered or discontinued, implant elimination could possibly be essential and the patient should then be dealt with that has a buprenorphine dosage form that permits dose changes. If a CYP3A4 inducer is discontinued in a very client who is stabilized on buprenorphine, keep an eye on the client for overmedication.

pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of CYP3A4 inducers may decrease sufentanil degrees and efficacy, perhaps precipitating withdrawal syndrome in individuals who've developed physical dependence to sufentanil. Discontinuation of concomitantly applied CYP3A4 inducers may perhaps maximize sufentanil plasma concentration.

pentobarbital will minimize the level or impact of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Potent CYP3A4 inducers could minimize suvorexant efficacy; if greater suvorexant dose demanded, usually do not exceed 20 mg/day

pentobarbital will lower the read more extent or impact of rolapitant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Very long-time period coadministration of robust CYP3A4 inducers with rolapitant may appreciably reduce rolapitant efficacy.

pentobarbital will reduce the extent or effect of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Not known.

Contraindicated (1)pentobarbital will reduce the extent or impact of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will minimize the extent or effect of nateglinide by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.

pentobarbital will lower the level or result of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

pentobarbital will decrease the level or impact of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

pentobarbital will reduce the level or impact of dasatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

과량일시, 펜토바르비탈은 호흡기를 억제시켜 죽음에 이르게 한다. 미국에서, 펜토바르비탈은 사형에 사용된다.

pentobarbital will decrease the extent or influence of fludrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

pentobarbital will decrease the extent or effect of meloxicam by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Not known.

pentobarbital will decrease the level or outcome of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Stay away from coadministration of lefamulin with powerful or average CYP3A inducers unless the advantage outweighs pitfalls. Keep track of for lessened efficacy.